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AllerMAbs.jpg

艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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Toronto Research Chemicals.jpg

Toronto Research Chemical建立于1982年,致力于为生物医药研发人员提供小分子有机物,库存超过57000种,并通过一系列方法保证标准物质的纯度。

 

Toronto Research Chemicals, TRC, was founded in 1982 by Dr. David Dime to manufacture and supply researchers in the biomedical fields with specialized complex organic small molecules that were not commercially available. In 1983, the company was incorporated in Ontario as Toronto Research Chemicals Inc. It was initially located at the University of Toronto. As the business expanded, larger facilities were required to accommodate the growth.

 

Today, Toronto Research Chemicals Inc. employs about 150 full time staff, of which approximately 80 are PHD's, operating in a 65,000 square foot facility. TRC, currently manufactures and distributes in excess of 33,000 products to more than 65 countries.

 

Toronto Research Chemical的产品涵盖:

Activators; Affinity Chromatography; Agonists; Agro-Products; Aldehyde Labeling Reagents; Aldehydes; Amines; Amino Acids & Derivatives; Anti-virals; Antibiotics; Apoptosis; Benzodiazepines; Biotin Derivatives; Boron Derivatives; Carbohydrates; Catalysts; Charged Bifunctional Reagents; Charged Monofunctional Reagents; Chelating Agents & Ligands; Chiral Reagents; Chromatography Media; Cross Linking Reagents; Crosslinker; CyanineDyes; Detergents; Diagnostics; Dihydropyridine; Dopamines; DrugAnalogues; ElectrophoresisMaterials; Environmental; Enzyme Substrates; Ephedrines; Fatty Acids & Derivatives; Fentanyls; Fluorescent Labels &Indicators; Glucuronides; Glutathione S-Transferase Agents; Glycerols; Glycosidase Inhibitors; Heterocycles; Hydantoins; Impurities; Indole Derivatives; Inhibitors; Inositols; Isotope Labelled Compounds; Labeling and Diagnostics Reagents; Lipids; Lysergic Acid and Derivatives; Maleimide Derivatives; Mercaptans/Thiols; Metabolites; Methadones and Analogues; Miscellaneous Compounds; Morphine Based Alkaloids; MTS & Sulfhydryl Active Compounds; Mutagenesis Research Chemicals; Neurochemicals; Neutral Bifunctional Reagents; Neutral Monofunctional Reagents; Nicotine Derivatives; Nitric Oxide Reagents; Non-nucleoside Reverse Transcriptase; Nucleotides; Oligosaccharides; Opium Alkaloids - Natural and Derivatives; Peptides; Pharmaceuticals; Phenethylamines; Phosphorylating and Phosphitylating Agents; Phosphorylcholine Derivatives; Photoaffinity Labels; Polyethyleneglycol Derivatives; Polymers; Protein Kinase Inhibitors and Activators; Pyridyl Disulfides; Retinoids; Selenium Compounds; Sphingosine Derivatives; Spin Labeling Compounds; Steroids; Sulfonyl Chlorides; Tyrosine Kinase Inhibitors; Wittig Reagents.

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艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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Athern Research & Technology.jpg

艾美捷科技特约代理Athens Research & Technology产品。


Athens Research & Technology公司位于美国乔治亚州雅典市,从1986年以来一直致力于纯化高纯度,高活性的人类蛋白质和开发这些蛋白的多克隆抗血清。常规产品包括丝氨酸蛋白酶、蛋白酶抑制剂、中性粒细胞酶、载脂蛋白、脂蛋白,血小板蛋白、转铁蛋白、免疫球蛋白等。

 

Athens Research & Technology Inc. has been purifying human proteins and developing polyclonal antisera to those proteins since 1986. We specialize in highly pure, highly active human proteins. We routinely purify serine proteases, protease inhibitors, neutrophil enzymes, apolipoproteins, lipoproteins, platelet proteins, transferrins, immunoglobulins, and more. Researchers around the world have been purchasing these research reagents from us for more than twenty-five years. You'll see our products referenced in major scientific publications in studies of inflammation, coronary disease, autoimmune disease, cancer, Alzheimer's Disease, and so on.

 

Athens Research & Technology公司的主要产品包括:

Coagulation Factors

Enzymes & Inhibitors

Immunoglobulins

Lipoproteins & Apolipoproteins

Low Endotoxin Level Proteins

Milk & Platelet Proteins

Neutrophil Proteins

Transferrins & Apotransferrins

Transport/Other Proteins

All Human Proteins

All Animal Proteins

Antibodies

Assay Kits

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Roboz Surgical Instrument.jpg

Roboz Surgical Instrument公司一直为研究人员提供专门的、手工制作的外科器械,以满足他们独特的需求。Roboz Surgical Instrument公司是外科器械和相关产品的领先设计师和开发商,产品被世界各地的医疗保健和研究专业人士使用。

 

When Otto Roboz started the Roboz Surgical Instrument Company in 1953, his goal was to provide researchers with specialized, hand-crafted surgical instruments designed to meet their unique demands.  Since then, Roboz Surgical has grown into one of the life science market’s leading sources of quality surgical instruments. Although the work of the research community has changed quite a bit over the last 60 years, Roboz Surgical, through constant innovation, continues to provide the highest-quality instruments and unparalleled service, to meet and exceed all of our customers’ needs.

 

Today Roboz Surgical Instrument Company is a leading designer and developer of surgical instruments and related products. Our products are used by healthcare and research professionals worldwide. Throughout our history of over sixty years , the Roboz name has been synonymous with quality.

 

Roboz Surgical Instrument公司主要产品:

Bone Instruments

Clips & Clamps

General Micro Dissecting

Instrument Care and

Handling

Instrument Services

Misc. Instruments

Retractors

Scalpels

Scissors

Tweezers & Forceps

Vascular Access

Wound Closures

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艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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Encapsula NanoSciences.jpg

艾美捷科技特约代理Encapsula NanoSciences公司产品。


Encapsula NanoSciences是美国一家致力于提供基于脂质纳米微粒技术(脂质体)的研发和生产的高科技生物纳米技术公司,具有多项知识产权。Encapsula NanoSciences公司现拥有Clodrosome ® , Encapsome ®和Fluoroliposome ® 三个注册商标品牌,提供表面活性脂质体配方和生产服务,包括抗体/多肽交联(Immunosome)、氯磷酸盐脂质体(Clodrosome)及其对照脂质体(Encapsome)、阿霉素脂质体(Doxosome)、DNA和 RNA脂质体 (Genesome)、荧光脂质体(Fluoroliposome)、冻干ATP脂质体(ATPsome)、多款用于人造细胞模型的细胞脂质体(Cellsome)、用于抗肿瘤药物封装的脂质体、多款用于皮肤学及化妆品研发领域的脂质体(Cosmesome) 、以及用于姜黄色素(Curcusome)、肌醇(Inosisome)和宠物专用的营养补充剂脂质体 (Taurosome) 。公司产品服务于学术研究及工业生产等多个领域。通常根据客户需求提供实验室规模的预制脂质体产品。

 

Encapsula NanoSciences is a specialty company focused on providing liposome research, development and manufacturing expertise in the production of lipid-based nanoparticles, also known as liposomes, to clients and partners in both the academic and industrial sectors. Encapsula routinely provides custom laboratory-scale liposome preparations of drug encapsulated liposomes such as Clodrosome® (clodronate liposomes), Encapsome® (plain-control liposomes for clodronate liposomes), Doxosome™ (doxorubicin liposomes), Immunosome™ (reactive liposomes for antibody, protein conjugation), Immunodox™ (reactive liposomes for antibody, protein conjugation containing doxorubicin), Immunogene™ (reactive liposomes for antibody, protein conjugation containing genetic material), Immunofluor™ (reactive liposomes for antibody, protein conjugation containing fluorescent molecules for tracking), Genesome™ (liposomal DNA and RNA), Fluoroliposome™ (fluorescent liposomes), Atpsome™ (ATP liposomes), Cellsome™ (plain liposomes as artificial cell models) and Cosmesome™ (liposomes used in dermatology) to clients in universities and industrial research labs. Encapsula NanoSciences also recently introduced two oral liposomal product lines; NanoLife Nutra for pets and NanoLife Tonics for humans.

 

Encapsula NanoSciences的主要产品包括:

Plain Liposomes as Artificial Cell Models or as Control

Small Molecules Encapsulated into Liposomes

Magnetic Liposomes

Fluorescent Liposomes

Spin labeled Liposomes

Encapsulation of Genetic Materials into the Liposomes

Liposomes used for Electro-Injection

Long-Circulating Sterically Protected Liposomes

Surface Modification of Liposomes

pH Sensitive Liposomes (PSL)

Freeze-Dried Liposomal Systems

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艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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